International Circulation: Here is China a commonly used ingredient is MSG and you can find that in pretty much everything you eat. How do you feel about the differences between regular sea salt intake versus monosodium glutamate?
Dr Arnett: All salt is essentially sodium and so when you look at their effects on blood pressure they are really going to be equivalent in terms of their blood pressure effects. We really need to work to reduce the sodium in the diet whether it is sodium chloride or MSG.
《国际循环》:味精是中国一个极其常用的调味料,在几乎所有食物中都含有。你觉得在盐和味精摄入量之间的差异是什么?
Arnett博士:所谓盐会影响血压是实质是钠对血压的影响,故从这一点上来说两者(盐和味精)是等效的。所以我们真正需要努力的是减少饮食中钠含量,不管是氯化钠还是谷氨酸钠。
International Circulation: What kinds of antihypertensive drugs are most effective in reducing the risk of stroke?
Dr Arnett: The most recent large scale study that was done in the US to address that question, the ALLHAT study, really found that the ACE inhibitors, diuretics, calcium antagonists and alpha-receptor blockers were all pretty much equally effective. I think the real key is getting your blood pressure to goal which may mean that it takes more than one of those agents to get you to a goal blood pressure of <120/80mmHg. I think there is not one superior agent but finding the right drug, the right dose and combining it with other drugs. In terms of cost, all of those products are now off patent so they have really dramatically reduced in price.
《国际循环》:什么类型的抗高血压药物能够有效的减少卒中的危险?
Arnett博士:ALLHAT研究是美国最近完成的大规模临床研究,正好能够回答这个问题。ACEI、利尿剂、钙拮抗剂和a受体阻滞剂在减少卒中方面几乎同样有效。我认为真正的关键是让血压达标,这可能意味着需要采取不止一个措施来让目标血压小于120/80 mmHg。找到合适的药物、正确的剂量并联合使用是最紧迫的。在成本方面,现在所有这些产品专利都到了限期,极大地降低了价格。
International Circulation: As the AHA’s first epidemiologist President, what perspectives do you hope this will bring to your leadership?
Dr Arnett: I am just delighted to be the first epidemiologist. Being an epidemiologist, I am really concerned about prevention and so from my perspective it is really about taking my lifelong passion for prevention and driving that message home in every place I visit.
《国际循环》:作为AHA的第一个流行病学家,您希望带来什么新观点吗?
Arnett博士:对于这个“第一”我非常高兴,作为流行病学家,我为预防医学的发展担忧,在我看来这是需要花费毕生精力进行的事业,我会在所到之处大力宣扬。